In this study of electronic health records of 38 286 low-risk patients with mild hypertension, no evidence of an association was found between exposure to antihypertensive treatment and mortality or cardiovascular disease. There was evidence that treatment may be associated with an increased risk of adverse events, such as hypotension, syncope, and acute kidney injury.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2708195
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2708195